Synthesis and Molecular Docking Studies of New Series of Bis-Schiff Bases Thiadiazoles Derived From Disulfides and Thioethers with Potent Antibacterial Properties

Two new series of various heterocyclic bis-Schiff bases Thiadiazoles disulfides and thioethers are synthesized. The first was the synthesis thiadiazole (4a-h) synthesized from their corresponding Schiff after oxidation by hydrogen peroxide. second base (7a-h). It obtained reaction bis-thiadiazole diamine (6) with different aldehyde. generated reacting dibromoethane in dimethylformamide triethylamine as a catalyst. All compounds were analyzed using FT-IR, 1H-NMR, 13C-NMR, C-APT techniques. screened against two gram-positive bacteria (Staphylococcus streptococcus), strains gram-negative (E. coli klebsiella) comparison to standard strong antibiotic drugs (ciprofloxacin vancomycin). Generally, all showed highly antibacterial properties, particularly, (4b,4f, 7b) which observed potent anti-bacterial properties both gram- (positive, negative) even higher than drugs. Lastly, molecular docking studies also applied find binding affinity active sides products target proteins.